Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1999 Sep 20;9(18):2741-6.

Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.

Author information

1
Department of Biochemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.

Abstract

Resistance to carbapenem antibiotics in gram-negative bacteria is due, in part, to expression of a wide spectrum metallo-beta-lactamase, which renders the drug inactive. Biphenyl tetrazoles containing 3-n-butyl-1-phenylpyrazole-5-carboxylates or the corresponding 5-ethyl esters were found to inhibit metallo-beta-lactamases as well as renal dehydropeptidase I to a lesser extent.

PMID:
10509927
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center