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Bioorg Med Chem Lett. 1999 Sep 20;9(18):2731-6.

Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs.

Author information

1
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. jszhang@mail.shcnc.ac.cn

Abstract

A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.

PMID:
10509925
DOI:
10.1016/s0960-894x(99)00472-2
[Indexed for MEDLINE]

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