Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects

H Y Choo; B J Chung; S H Chung

doi:10.1016/s0960-894x(99)00471-0

Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2727-30. doi: 10.1016/s0960-894x(99)00471-0.

Authors

H Y Choo¹, B J Chung, S H Chung

Affiliation

¹ School of Pharmacy, Ewha Womans University, Seoul, Korea.

PMID: 10509924
DOI: 10.1016/s0960-894x(99)00471-0

Abstract

Piperazine derivatives were prepared as histamine antagonists. Some of the synthesized compounds showed dual antagonistic activity against bradykinin as well as histamine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bradykinin Receptor Antagonists*
Guinea Pigs
Histamine H1 Antagonists / chemical synthesis*
Histamine H1 Antagonists / pharmacology*
In Vitro Techniques
Piperazines / chemical synthesis*
Piperazines / pharmacology*
Rats

Substances

Bradykinin Receptor Antagonists
Histamine H1 Antagonists
Piperazines