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Curr Opin Neurobiol. 1999 Oct;9(5):566-70.

Polyglutamine diseases: protein cleavage and aggregation.

Author information

1
Howard Hughes Medical Institute Baylor College of Medicine Houston, Texas 77030, USA. hzoghbi@bcms.tm.edu

Abstract

Neuronal aggregates of the disease-causing protein, often in the nucleus of affected cells, are a pathological hallmark of the neurodegenerative diseases known as polyglutamine disorders. It was suggested that these nuclear aggregates are the cause of these disorders. However, recent evidence suggests that the aggregates, in fact, are not the pathogenic basis and, instead, may play a role in sequestration of the pathogenic protein.

PMID:
10508741
DOI:
10.1016/S0959-4388(99)00013-6
[Indexed for MEDLINE]

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