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Curr Opin Genet Dev. 1999 Oct;9(5):595-603.

APC: the plot thickens.

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Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK.


Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.

[Indexed for MEDLINE]

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