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Curr Opin Genet Dev. 1999 Oct;9(5):595-603.

APC: the plot thickens.

Author information

1
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. mb2@mrc-lmb.cam.ac.uk.

Abstract

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.

PMID:
10508699
[Indexed for MEDLINE]

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