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Curr Opin Genet Dev. 1999 Oct;9(5):522-9.

Controls in patterning and diversification of somatic muscles during Drosophila embryogenesis.

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Department of Biochemistry and Molecular Biology Mount Sinai School of Medicine Box 1020, New York, New York 10029, USA.


Recent genetic studies in Drosophila have provided important insights into the pathways determining the formation and diversification of body wall muscles. These pathways control a progressive subdivision of the mesoderm, ultimately leading to the specification of individual cells, the muscle founders, which are endowed with genetic programs capable of generating distinct muscle fibers. A network of activities of transcriptional regulators, signaling pathways, and lineage genes is beginning to emerge which controls successive steps of this muscle patterning and differentiation process.

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