Format

Send to

Choose Destination
Curr Opin Genet Dev. 1999 Oct;9(5):559-65.

Notch around the clock.

Author information

1
Laboratoire de Génétique et de Physiologie du Développement (LGPD) CNRS-INSERM-Université de la Méditerranée - AP de Marseille Campus de Luminy, Case 907, 13288, Marseille,France. pourquie@ibdm.univ-mrs.fr

Abstract

The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems.

PMID:
10508694
DOI:
10.1016/s0959-437x(99)00011-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center