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Curr Opin Genet Dev. 1999 Oct;9(5):499-504.

Nuclear receptor cofactors as chromatin remodelers.

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Howard Hughes Medical Institute Department of Molecular Biology and Cell Biology University of California Berkeley, California 94720, USA. bdlemon@uclink.


Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters.

[Indexed for MEDLINE]

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