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Curr Opin Genet Dev. 1999 Oct;9(5):515-21.

From factors to mechanisms: translation and translational control in eukaryotes.

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Gene Expression Programme European Molecular Biology Laboratory Meyerhofstrasse 1, D-69117, Heidelberg, Germany.


Biochemical and genetic studies are revealing a network of interactions between eukaryotic translation initiation factors, further refining or redefining perceptions of their function. The notion of translated mRNA as a 'closed-loop' has gained support from the identification of physical and functional interactions between the two mRNA ends and their associated factors. Translational control mechanisms are beginning to unravel in sufficient detail to pinpoint the affected step in the initiation pathway.

[Indexed for MEDLINE]

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