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Curr Opin Chem Biol. 1999 Oct;3(5):614-22.

Metallo-beta-lactamase: structure and mechanism.

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The Pennsylvania State University, Department of Chemistry, 152 Davey Laboratory, University Park, PA 16802, USA.


This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of beta-lactam antibiotics.

[Indexed for MEDLINE]

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