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Curr Opin Chem Biol. 1999 Oct;3(5):607-13.

Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis.

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  • 1Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.


Within the past 18 months work has continued on the structure and mechanisms of enzymes involved in the diaminopimelic acid/lysine biosynthetic pathway. A novel structure has been determined for a PLP-independent epimerase, and structures with bound substrates have been solved for two other enzymes. Additionally, new studies have appeared describing the chemical mechanisms of three enzymes in the pathway.

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