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Curr Opin Cell Biol. 1999 Oct;11(5):591-6.

Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases.

Author information

1
Division of Signal Transduction Nara Institute of Science and Technology 8916-5, Takayama, Ikoma, 630-0101, Japan. kaibuchi@bs. aist-nara.ac.jp.

Abstract

Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion. IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and beta-catenin and induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.

PMID:
10508646
DOI:
10.1016/s0955-0674(99)00014-9
[Indexed for MEDLINE]

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