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Angew Chem Int Ed Engl. 1999 Sep;38(17):2588-2590.

Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid.

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1
Lehrstuhl für Organische Chemie I der Universität, Universitätsstrasse 150, D-44780 Bochum (Germany).

Abstract

It works even without the enzyme: The formation of the bioactive form 1 of isoniazid inside Mycobacterium tuberculosis does not depend on specific interactions within the active site of the inhibited enzyme, but rather relies on the fast addition of acyl radicals to electron-deficient heterocycles such as NAD(+).

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