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Antimicrob Agents Chemother. 1999 Oct;43(10):2559-61.

Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing.

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1
Division of Anaesthesiology and Intensive Care, University of Queensland, Queensland, Australia. jlipman@gasbone.herston.uq.edu.au

Abstract

The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.

PMID:
10508045
PMCID:
PMC89521
[Indexed for MEDLINE]
Free PMC Article
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