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Pain. 1999 Oct;83(1):101-3.

Low-dose subcutaneous ketamine infusion and morphine tolerance.

Author information

1
Pain Clinic, Department of Anaesthesiology and Intensive Care, Haukeland University Hospital, Bergen, Norway. rbel@haukeland.no

Abstract

The NMDA receptor has been reported to be involved in opioid tolerance. Adjuvant subcutaneous infusion treatment with (very) low-dose ketamine, a NMDA receptor antagonist, improves analgesia and at the same time appears to reduce morphine tolerance. Three cases are presented.

PMID:
10506678
[Indexed for MEDLINE]

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