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Kidney Int. 1999 Oct;56(4):1254-7.

Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells.

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Department of Pharmacology, University College Dublin, Ireland.


We studied the effects of cyclosporine A (CsA) on the proliferation of LLC-PK1 proximal tubule epithelial cells. DNA damage was found to be an early event in CsA nephrotoxicity and could be a sensitive indicator of CsA injury in renal epithelial cells. Cell cycle arrest induced by CsA was coincident with elevated p53 levels. It is possible that trans-activating p21 may mediate the halting of the cell cycle through the CsA-induced accumulation of p53.

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