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Mol Gen Genet. 1999 Aug;262(1):163-72.

Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

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Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), Epalinges.


The fission yeast gene cps1, which encodes the catalytic subunit of beta-glucan synthase, was isolated in a screen for mutants that show an increase in ploidy at the restrictive temperature. cps1 mutants display defects in both polarity and septation at the permissive temperature, and become swollen and multinucleate at the restrictive temperature. Analysis of the interaction of cps1 with other mutations suggests the existence of a septation checkpoint, which requires the activity of the protein kinase weel for function.

[Indexed for MEDLINE]

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