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Nat Med. 1999 Oct;5(10):1150-6.

Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells.

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Division of Basic Immunology, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA.

Erratum in

  • Nat Med 2000 Feb;6(2):229. Kanehio A [corrected to Kanehiro A].


The mechanisms regulating airway function are complex and still poorly understood. In diseases such as asthma, involvement of immune-dependent mechanisms has been suggested in causing changes in airway responsiveness to bronchoconstrictors. We now demonstrate that gammadelta T cells can regulate airway function in an alphabeta T cell-independent manner, identifying them as important cells in pulmonary homeostasis. This function of gammadelta T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense.

[Indexed for MEDLINE]

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