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Neuroreport. 1999 Jun 3;10(8):1747-50.

Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder.

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Karolinska Institute, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.


In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.

[Indexed for MEDLINE]

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