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Peptides. 1999;20(9):1035-42.

Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family.

Author information

1
Department of Entomology, University of Georgia, Athens 30602, USA. mbrown@bugs.ent.uga.edu

Abstract

A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and shown to exist as a single genomic copy. The encoded, putative prepropeptide can be processed into an amidated NPF with 36 residues that is related to invertebrate NPF's and the neuropeptide Y family of vertebrates. In situ hybridization and immunocytochemistry showed that Drosophila NPF was expressed in the brain and midgut of fly larvae and adults.

PMID:
10499420
DOI:
10.1016/s0196-9781(99)00097-2
[Indexed for MEDLINE]

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