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Eur J Pharmacol. 1999 Aug 20;379(1):R1-2.

Enhancement of memory in cannabinoid CB1 receptor knock-out mice.

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CNS Department, Research Center of Vitry-Alfortville, Rhône-Poulenc Rorer, Vitry-sur-Seine, France.


We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB receptors play a crucial role in the process of memory storage and retrieval.

[Indexed for MEDLINE]

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