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FEMS Microbiol Lett. 1999 Sep 15;178(2):271-5.

Proteolytic cleavage of the repressor (BlaI) of beta-lactamase synthesis in Staphylococcus aureus.

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1
Department of Biochemistry, University of Oxford, UK.

Abstract

The proteolytic cleavage of BlaI was shown to correlate with beta-lactamase synthesis in Staphylococcus aureus. BlaI was found to be autoregulatory when expressed from the blaZ promoter. Insertion of a 10-bp linker into the SnaBI site of blaRI resulted in constitutive synthesis of beta-lactamase.

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