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Bioorg Med Chem Lett. 1999 Sep 6;9(17):2549-54.

Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratorie, Rahway, NJ 07065, USA.

Abstract

Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.

PMID:
10498206
[Indexed for MEDLINE]

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