Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 1999 Sep 24;285(5436):2126-9.

Drosophila S6 kinase: a regulator of cell size.

Author information

1
Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland.

Abstract

Cell proliferation requires cell growth; that is, cells only divide after they reach a critical size. However, the mechanisms by which cells grow and maintain their appropriate size have remained elusive. Drosophila deficient in the S6 kinase gene (dS6K) exhibited an extreme delay in development and a severe reduction in body size. These flies had smaller cells rather than fewer cells. The effect was cell-autonomous, displayed throughout larval development, and distinct from that of ribosomal protein mutants (Minutes). Thus, the dS6K gene product regulates cell size in a cell-autonomous manner without impinging on cell number.

PMID:
10497130
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center