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Semin Immunol. 1999 Oct;11(5):319-28.

Allelic exclusion in B and T lymphopoiesis.

Author information

1
Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, The Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Abstract

The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin structure, and induce V(D)J recombination on one allele preferentially.

PMID:
10497086
DOI:
10.1006/smim.1999.0188
[Indexed for MEDLINE]

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