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Infect Immun. 1999 Oct;67(10):5541-4.

Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia.

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  • 1Rayne Laboratories, University of Edinburgh, Scotland. mmcelroy@ed.ac.uk

Abstract

We have shown that injury to alveolar epithelial type I cells may account, in part, for damage to the air-blood barrier of the lung in a rat model of Staphylococcus aureus pneumonia. We have also shown that alpha-toxin is an important cause of damage to the air-blood barrier; however, our data suggest that the toxin is not acting directly on alveolar type I cells.

PMID:
10496947
PMCID:
PMC96922
[PubMed - indexed for MEDLINE]
Free PMC Article
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