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Infect Immun. 1999 Oct;67(10):5518-21.

Role of gamma interferon in controlling murine chlamydial genital tract infection.

Author information

1
Department of Infectious Diseases, City of Hope National Medical Center, Duarte, California 91010, USA. jito@coh.org

Abstract

Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.

PMID:
10496942
PMCID:
PMC96917
[Indexed for MEDLINE]
Free PMC Article

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