Format

Send to

Choose Destination
Diabetes Metab Res Rev. 1999 Jul-Aug;15(4):247-53.

ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.

Author information

1
Division and Research Unit of Endocrinology, Scientific Institute 'Casa Sollievo della Sofferenza', San Giovanni Rotondo (FG), Italy. sdecosm@tin.it

Abstract

BACKGROUND:

Genetic factors are involved in the development of diabetic nephropathy in Type 1 diabetes. We have examined the association of four candidate genes, angiotensin converting enzyme (ACE): insertion/deletion (I/D) polymorphism, plasminogen activator inhibitor-1 (PAI-1): 4G/5G polymorphism, decorin: 179/183/185 polymorphism and Werner syndrome helicase: C/R polymorphism, with the presence of diabetic nephropathy in Type 1 diabetic patients.

METHODS:

175 Type 1 diabetic patients with albuminuria (59 with microalbuminuria and 116 with macroalbuminuria) were compared with 136 Type 1 diabetic patients with normoalbuminuria and duration of disease longer than 15 years (mean+/-SD: 25+/-8 years). 200 non-diabetic subjects were also studied as background population.

RESULTS:

We found no association in the polymorphism of the four genes examined between patients with and without diabetic nephropathy and the control subjects.

CONCLUSIONS:

The genes studied are unlikely to be involved in the susceptibility to nephropathy in Type 1 diabetic patients.

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center