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Mech Dev. 1999 Sep;87(1-2):213-6.

Gata2 and Gata3: novel markers for early embryonic polarity and for non-neural ectoderm in the chick embryo.

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Department of Genetics and Development, Columbia University, 701 West 168th Street #1602, New York, New York 10032, USA.


We have investigated in detail the expression patterns of two Gata genes, cGata2 and cGata3, during early chick development. In addition to confirming previously described expression of these two genes in developing brain, kidney and blood islands, this study reveals several important novel expression domains during very early stages of development. cGata2 is expressed in the area opaca in pre-primitive streak stages, forming a gradient along the A-P axis (strongest anteriorly). Both genes are expressed strongly in the entire non-neural ectoderm from stage 4+, and neither is expressed in prospective neural plate at any stage. Unlike other previously described non-neural markers, neither gene is expressed in the dorsal neural tube. We also describe dynamic expression of cGata2 and cGata3 during eye, ear and gut development.

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