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Leuk Lymphoma. 1999 Aug;34(5-6):473-80.

Suicide gene-mediated modulation of graft-versus-host disease.

Author information

1
Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS ESA 7087, Groupe Hospitalier Pitié-Salpêtrière, Paris.

Abstract

The development of suicide genes and progress in retroviral gene transfer to T-cells open new perspectives for the treatment of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) for leukemia and lymphoma. Indeed, suicide genes that metabolize inactive prodrugs into compounds toxic for dividing cells provide a powerful means for the pharmacogenetic control of T-cell reactivity. Here, we demonstrate the selective destruction of activated TK-transgenic T-cells in vivo and develop two new transgenic lines which should be useful for preclinical studies of suicide gene therapy strategies for GVHD.

PMID:
10492070
DOI:
10.3109/10428199909058474
[Indexed for MEDLINE]

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