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Nat Neurosci. 1999 Oct;2(10):855-6.

Selective gene expression increases behavioral sensitivity to cocaine.

Author information

1
National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, Maryland 20892-9669, USA. shyman@nih. gov.

Abstract

Addictive drugs induce a truncated form of fosB in the striatum. A new study shows that mice engineered to mimic this expression pattern are abnormally sensitive to cocaine.

PMID:
10491599
DOI:
10.1038/13147
[Indexed for MEDLINE]

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