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Oncogene. 1999 Sep 2;18(35):5010-4.

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.

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Program in Human Genetics and Molecular Biology, The Johns Hopkins University, Baltimore, Maryland, MD 21231, USA.


The majority of human colorectal cancers have elevated beta-catenin/TCF regulated transcription due to either inactivating mutations of the APC tumor suppressor gene or activating mutations of beta-catenin. Surprisingly, one commonly used colorectal cancer cell line was found to have intact APC and beta-catenin and no demonstrable beta-catenin/TCF regulated transcription. However, this line did possess a truncating mutation in one allele of CDX2, a gene whose inactivation has recently been shown to cause colon tumorigenesis in mice. Expression of CDX2 was found to be induced by restoring expression of wild type APC in a colorectal cancer cell line. These findings raise the intriguing possibility that CDX2 contributes to APC's tumor suppressive effects.

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