Abstract
Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. This signaling mechanism may be coordinated by the interaction of components of the protein kinase cascade with scaffold proteins. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates signaling by the mixed-lineage kinase (MLK)-->MAP kinase kinase 7 (MKK7)-->JNK pathway. The scaffold proteins JIP1 and JIP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell surface. The JIP proteins function by aggregating components of a MAP kinase module (including MLK, MKK7, and JNK) and facilitate signal transmission by the protein kinase cascade.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Amino Acid Sequence
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Carrier Proteins / genetics
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Carrier Proteins / isolation & purification
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Carrier Proteins / metabolism*
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Cell Compartmentation
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Cloning, Molecular
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JNK Mitogen-Activated Protein Kinases
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MAP Kinase Kinase 7
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MAP Kinase Kinase Kinases / metabolism*
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Mitogen-Activated Protein Kinase Kinases / metabolism*
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Mitogen-Activated Protein Kinases / metabolism*
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Molecular Sequence Data
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Protein Binding
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Protein Structure, Quaternary
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Sequence Homology, Amino Acid
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Signal Transduction
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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MAPK8IP1 protein, human
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MAPK8IP2 protein, human
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JNK Mitogen-Activated Protein Kinases
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Mitogen-Activated Protein Kinases
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MAP Kinase Kinase Kinases
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MAP Kinase Kinase 7
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MAP2K7 protein, human
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Mitogen-Activated Protein Kinase Kinases