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Essays Biochem. 1998;33:43-52.

Mitochondria in the life and death of neurons.

Author information

1
CNS Research Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

A prolonged decrease in ATP levels underlies a number of neurodegenerative disorders. Defects in oxidative phosphorylation are associated with a number of neurodegenerative disorders. Mitochondria also play an important role in mediating the initiation of apoptosis.

PMID:
10488440
[Indexed for MEDLINE]

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