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Biochem Biophys Res Commun. 1999 Sep 16;263(1):201-5.

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

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Department of Biochemistry, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA.


The present studies examined the effects of growth hormone (GH) on lipolysis and leptin release by adipose tissue from mice incubated for 24 h in primary culture. In adipose tissue from control mice GH enhanced lipolysis without affecting leptin release. The lipolytic action of GH was unaffected in adipose tissue from Stat5b-/- male mice but leptin release was enhanced by GH in fat from Stat5b-/- mice. In adipose tissue from Stat5ab-/- female mice no significant lipolytic action of GH was seen but leptin release was enhanced by GH. An insulin-like effect of GH on glucose conversion to lactate was also seen in mice deficient in Stat5ab-/-. These results suggest that the lipolytic action of GH involves the Stat5 proteins while the insulin-like effects of GH on glucose metabolism and leptin release involve different mechanisms.

[Indexed for MEDLINE]

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