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Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10854-6.

Subsurface tumor progression investigated by noninvasive optical second harmonic tomography.

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  • 1Institute for Ultrafast Spectroscopy and Lasers, New York State Center for Advanced Technology, Department of Energy, New York, USA.


Nonlinear optical imaging with femtosecond (10(-15)-second) laser technology was used to evaluate the subsurface tumor progression in control, dysplasia, and cancerous 7, 12-dimethylbenz[a]anthracene-treated hamster cheek pouch mucosa tissues. Two-dimensional images of hamster cheek pouch mucosa tissues were obtained by scanning the second harmonic signal at various sagittal and axial positions. The spatial mapping of the second harmonic signals showed depth differentiation between normal, dysplasia, and a more advanced cancerous state. This nonlinear optical method offers a noninvasive in situ imaging tool to the medical community.

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