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Trends Cell Biol. 1999 Oct;9(10):387-94.

Septins: cytoskeletal polymers or signalling GTPases?

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  • 1Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.


Septins are a family of conserved proteins that have been implicated in a variety of cellular functions involving specialized regions of the cell cortex and changes in cell shape. The biochemistry and localization of septins suggest that they form a novel cytoskeletal system or that they function as scaffolds for the assembly of signalling complexes. This article discusses septin biochemistry and septin-interacting proteins, focusing on the missing link between the structure and biochemical properties of septin proteins, and on how they function at a molecular level in processes such as cytokinesis and yeast budding.

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