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Lab Anim Sci. 1999 Aug;49(4):358-62.

Neurons and mechanisms of neuronal death in neurodegenerative diseases: a brief review.

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1
ZymoGenetics, Seattle, Washington, USA.

Abstract

BACKGROUND AND PURPOSE:

Degenerative diseases of the central nervous system are a heterogenous group of slowly progressive disorders. A common feature of this group, which includes Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, is gradual loss of specific populations of neurons.

METHODS:

A series of reports about neurodegenerative diseases and their relevant animal models, as well as a brief overview of the normal neuron and mechanisms of neuronal degeneration and death, is presented.

CONCLUSION:

Study of the aforementioned animal models, spontaneously occurring and experimentally induced, have provided important insights into the pathogenesis of these disorders and the development of effective therapeutic strategies.

PMID:
10480639
[Indexed for MEDLINE]

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