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J Nat Prod. 1999 Aug;62(8):1110-3.

DNA polymerase beta inhibitors from Sandoricum koetjape.

Author information

1
Departments of Chemistry and Biology, University of Virginia Charlottesville, Virginia 22901, USA.

Abstract

Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase beta inhibition led to the isolation of three active compounds (1-3) having IC(50) values from 20 to 36 microM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase beta with IC(50) values ranging from 16 to 36 microM.

PMID:
10479314
DOI:
10.1021/np990104r
[Indexed for MEDLINE]

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