Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 1999 Oct;180(4):1356-60.

The effect of age and natural priming on the IgG and IgA subclass responses after parenteral influenza vaccination.

Author information

1
The Norwegian Medicines Control Authority, Sven Oftedals vei 6, N-0950 Oslo, Norway. Abdullah.el-madhun@slk.no

Abstract

This study investigated the effect of natural priming and age on serum IgG and IgA subclass responses after parenteral trivalent influenza vaccination. Sera from 18 young children and 8 adults were collected at various times after vaccination. An ELISA was performed to quantify the concentrations of antibody subclasses. The children were divided into primed and unprimed groups based on the presence of prevaccination serum antibodies. In both children and adults, IgG1 and IgA1 were the predominant IgG and IgA subclasses detected after vaccination. No IgG2 responses were detected in sera of unprimed children, and the proportion of the IgG2 response was lower in primed children than in adults. This suggests that the IgG2 immune response in young children is dependent on previous priming and may mature later than the other IgG subclasses after parenteral influenza vaccination.

PMID:
10479172
DOI:
10.1086/315003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center