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Bioorg Med Chem Lett. 1999 Aug 16;9(16):2403-6.

NMR-based discovery of phosphotyrosine mimetics that bind to the Lck SH2 domain.

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1
Abbott Laboratories, Abbott Park, IL 60064, USA.

Abstract

Using an NMR-based screen, a series of novel phosphotyrosine mimetics were discovered that bind to the SH2 domain of Lck. These compounds may serve as useful leads for the design of nonpeptide inhibitors of SH2 domains with improved bioavailability and metabolic stability compared to the natural ligands that contain phosphotyrosine.

PMID:
10476877
DOI:
10.1016/s0960-894x(99)00403-5
[Indexed for MEDLINE]

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