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Bioorg Med Chem Lett. 1999 Aug 16;9(16):2335-8.

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

Author information

1
Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon. chpaul@ust.hk

Abstract

Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials. The optimum hybrid inhibitor (+/-)-9g is 13-fold more potent than (-)-huperzine A, and 25-fold more potent than tacrine.

PMID:
10476864
DOI:
10.1016/s0960-894x(99)00396-0
[Indexed for MEDLINE]

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