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Dermatology. 1999;199 Suppl 1:53-6.

Retinaldehyde alleviates rosacea.

Author information

1
Department of Clinical Research, Pierre Fabre Research Institute, Toulouse, France.

Abstract

BACKGROUND:

Anecdotal observations suggest that retinoic acid may be effective in mild rosacea.

AIM:

Our aim was to investigate, by an exploratory clinical and instrumental study, the effects of a topical formulation with the retinoic acid precursor retinaldehyde, in patients with vascular signs of facial rosacea.

METHODS:

Female patients were treated with a 0.05% retinaldehyde cream that was applied once daily for 6 months. Clinical assessments of persistent erythema and telangiectasia were performed every month, using a 4-point severity score (absent to severe). The clinical response for each parameter was defined as a decrease of at least 1 grade in the severity score. In addition, erythema was further evaluated by measurement of the a* parameter, using a spectrophotometer on lesional and nonlesional areas.

RESULTS:

A total of 23 women comprised the study population. At baseline, 10 patients had diffuse erythema, 3 patients had isolated telangiectasia and 10 patients had both. During retinaldehyde treatment, a clinical response was revealed in about 75% of the patients with erythema, after 5 months (p < 0.05). Similarly, isolated telangiectasia responded to retinaldehyde, although to a lesser extent and after a longer period of treatment (46% responders after 6 months, nonsignificant). Using the spectrophotometer, the a* parameter diminished in patients with erythema by about 15%, after 2 months of treatment (p = 0.001).

CONCLUSION:

This study indicates that retinaldehyde has beneficial effects on the vascular component of rosacea.

PMID:
10473962
DOI:
10.1159/000051380
[Indexed for MEDLINE]

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