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Clin Diagn Lab Immunol. 1999 Sep;6(5):725-8.

A new method with general diagnostic utility for the calculation of immunoglobulin G avidity.

Author information

1
Haartman Institute, Department of Virology, University of Helsinki, Helsinki, Finland.

Abstract

The reference method for immunoglobulin G (IgG) avidity determination includes reagent-consuming serum titration. Aiming at better IgG avidity diagnostics, we applied a logistic model for the reproduction of antibody titration curves. This method was tested with well-characterized serum panels for cytomegalovirus, Epstein-Barr virus, rubella virus, parvovirus B19, and Toxoplasma gondii. This approach for IgG avidity calculation is generally applicable and attains the diagnostic performance of the reference method while being less laborious and twice as cost-effective.

PMID:
10473525
PMCID:
PMC95762
[Indexed for MEDLINE]
Free PMC Article

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