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Mech Dev. 1999 Jun;84(1-2):69-73.

Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps.

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MRC Laboratory of Molecular Biology, Cambridge, UK.


We report the expression pattern of a new adenomatous polyposis coli (APC) homolog called E-APC during Drosophila development. E-APC protein is expressed in all embryonic and larval cells we have examined. In the early blastoderm embryo, we see a striking concentration of E-APC in the cortical actin caps. Microtubules are closely associated with these caps. Since human APC has been reported to bind to microtubules, we investigated whether the cortical E-APC co-localizes with tubulin. However, this was not the case, implying that the putative tubulin-binding property of human APC is not well conserved.

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