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Otolaryngol Head Neck Surg. 1999 Sep;121(3):220-3.

Effects of vasoactive topical agents on the survival of dorsal skin flaps in rats.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Boston University and Medical Center, MA 02118, USA.

Abstract

OBJECTIVE:

To evaluate 3 vasoactive topical agents regarding their ability to improve the survival of random skin flaps in rats.

METHOD:

Thirty-five adult Sprague-Dawley rats had a single 9 x 2 cm random skin flap raised with topical application of a white petroleum ointment (control group), prostaglandin E2, minoxidil, or nitroglycerin to the flap. The effect of the agents on the viability of the flaps was evaluated.

RESULTS:

The control group had an average survival area of 60.8% +/- 7.9%. The nitroglycerin and minoxidil groups were not significantly different, with an average area of survival of 60.1% +/- 8.1% and 63.3% +/- 4.7%, respectively. The prostaglandin E2 group had average area of survival of 74.2% +/- 10.5% (P = 0.002).

CONCLUSION:

Prostaglandin E2 demonstrated a significant increase in flap survival. Nitroglycerin ointment and minoxidil had no beneficial effects when compared with control.

PMID:
10471861
DOI:
10.1016/S0194-5998(99)70175-0
[Indexed for MEDLINE]

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