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FEBS Lett. 1999 Sep 3;457(3):470-4.

Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis.

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Department of Biochemistry, Institute of Medical Science, University of Tokyo, Tokyo, Japan.


Here we report the functional importance of profilin in various actin-mediated morphological changes using H119E mutant profilin I, which is deficient only in actin binding. In the case of actin-protrusive structures from the plasma membrane, H119E-profilin was shown to suppress the formation of Cdc42-induced actin microspikes and Rac-induced membrane ruffles. Conversely, Rho-induced stress fiber formation seemed to occur independently of H119E-profilin introduction. Furthermore, H119E-profilin blocked cleavage furrow ingression and subsequent adhesion to the substratum during cell division, a process in which actin plays indispensable roles.

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