Format

Send to

Choose Destination
Biochem Genet. 1978 Jun;16(5-6):469-75.

Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

Abstract

The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.

PMID:
104708
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center