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J Infect Dis. 1976 Jun;133(6):691-5.

Antistaphylococcal activity and beta-lactamase resistance of newer cephalosporins.


Four newer cephalosporins (cefazolin, cefamandole, SK&F 59962, and cefoxitin) were investigated for determination of their antistaphylococcal activity and relative stability to staphylococcal beta-lactamase (penicillinase). Crude preparations of beta-lactamase from recent clinical isolates of Staphylococcus aureus were used. Cefamandole and SK&F 59962 were highly active against both large and small inocula of staphylococci and were resistant to staphylococcal beta-lactamase. Cefoxitin, although resistant to beta-lactamase, possessed less antibacterial potency but was still approximately as active as methicillin. Cefazolin was somewhat more susceptible to staphylococcal beta-lactamase than the other three agents and resembled cephaloridine in this respect. With minor exceptions, a correlation was found between the susceptibility of different agents to beta-lactamase and the magnitude of the effect of inoculum size when the drugs were tested against large and small inocula of staphylococci.

[Indexed for MEDLINE]

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