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Trends Microbiol. 1999 Sep;7(9):366-72.

Defining the requirements for immunological control of mycobacterial infections.

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Dept of Infectious Diseases, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.


Tuberculosis remains a major public health problem throughout the world. Research into the immunological basis of the host-pathogen relationship has recently benefited from the fascinating convergence of genetic data from mouse models and from humans. Latency - the seemingly quiescent phase of bacterial persistence - is the central problem in controlling tuberculosis and will be the next frontier of research.

[Indexed for MEDLINE]

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